Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Liver Regeneration01:24

Liver Regeneration

4.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.2K
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

169
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
169

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Food-grade production of recombinant human serum albumin in <i>Kluyveromyces lactis</i> and evaluation of its biological activity.

Preparative biochemistry & biotechnology·2026
Same author

Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions.

MedComm·2026
Same author

The novel PDE5 inhibitor CPD1 attenuates pulmonary arterial hypertension through dual modulation of cGMP and TRPM8-mediated pathways.

Bioorganic chemistry·2026
Same author

Context-dependent actions of STING pathway in colitis and associated colon cancer.

Genes & diseases·2026
Same author

Genetically engineered Salmonella, SGN1, as a tumor microenvironment-targeting modality capable of methionine reduction for oral squamous cell carcinoma.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Reduced glycoprotein hormone β5 links male aging and testosterone decline to increased adiposity.

The Journal of clinical investigation·2026

Related Experiment Video

Updated: Jan 10, 2026

The Influence of Liver Resection on Intrahepatic Tumor Growth
07:55

The Influence of Liver Resection on Intrahepatic Tumor Growth

Published on: April 9, 2016

9.8K

Radix Rehmanniae Praeparata Extract Enhances Liver Regeneration Through AMPK-Driven Metabolic Reprogramming.

Changmeng Li1, Qi Zheng1, Fanghong Li1

  • 1School of Chinese Materia Medica, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Road, Beijing 100029, China.

Nutrients
|November 27, 2025
PubMed
Summary

Radix Rehmanniae Praeparata (RRP) significantly boosts liver regeneration by enhancing metabolic reprogramming through AMPK activation. This traditional Chinese medicine promotes lipid catabolism and energy production for improved liver recovery.

Keywords:
AMPKRadix Rehmanniae Praeparataliver regenerationmetabolic reprogramming

More Related Videos

Author Spotlight: Evaluating Therapeutic Strategies to Enhance Liver Regeneration
05:25

Author Spotlight: Evaluating Therapeutic Strategies to Enhance Liver Regeneration

Published on: May 24, 2024

3.3K
Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure
07:29

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure

Published on: August 14, 2017

15.3K

Related Experiment Videos

Last Updated: Jan 10, 2026

The Influence of Liver Resection on Intrahepatic Tumor Growth
07:55

The Influence of Liver Resection on Intrahepatic Tumor Growth

Published on: April 9, 2016

9.8K
Author Spotlight: Evaluating Therapeutic Strategies to Enhance Liver Regeneration
05:25

Author Spotlight: Evaluating Therapeutic Strategies to Enhance Liver Regeneration

Published on: May 24, 2024

3.3K
Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure
07:29

Rat Model of the Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy ALPPS Procedure

Published on: August 14, 2017

15.3K

Area of Science:

  • Hepatology and Regenerative Medicine
  • Metabolic Biochemistry
  • Pharmacology

Background:

  • Liver regeneration is crucial for hepatic mass restoration post-injury, driven by metabolic reprogramming.
  • Radix Rehmanniae Praeparata (RRP), a traditional Chinese medicine, influences glucose and lipid metabolism.
  • Understanding RRP's role in liver regeneration is vital for therapeutic applications.

Purpose of the Study:

  • To evaluate the effects of RRP on liver regeneration.
  • To elucidate the underlying mechanisms of RRP-induced metabolic reprogramming.
  • To identify key targets of RRP in hepatocyte proliferation.

Main Methods:

  • Utilized a 70% partial hepatectomy (PHx) mouse model.
  • Performed integrated transcriptomic and metabolomic analyses.
  • Validated findings in AML12 hepatocytes and primary mouse hepatocytes.

Main Results:

  • RRP significantly enhanced liver regeneration, indicated by increased hepatocyte proliferation markers.
  • RRP promoted lipid catabolism and H3K27ac remodeling-dependent proliferation via increased acetyl-CoA flux.
  • RRP enhanced carbohydrate metabolism, pentose phosphate pathway activity, and mitochondrial integrity, with AMPK activation mediating these effects.

Conclusions:

  • RRP promotes liver regeneration through AMPK-mediated metabolic reprogramming.
  • RRP enhances lipid catabolism, energy production, and nucleotide synthesis.
  • RRP demonstrates therapeutic potential for metabolic adaptation and recovery in liver disease.