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Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions.
Jiaorong Qu1, Wenqing Qin1, Minghang Dong1
1Beijing University of Chinese Medicine Beijing China.
Medcomm
|May 6, 2026
Summary
Liver fibrosis, a major cause of liver disease, involves complex molecular processes. This review synthesizes current knowledge on fibrogenesis and therapeutic strategies, offering insights into future treatments for liver fibrosis.
Area of Science:
- Hepatology and Gastroenterology
- Molecular Biology
- Translational Medicine
Background:
- Liver fibrosis is a critical pathological process leading to end-stage liver disease, driven by factors like viral hepatitis and metabolic-associated steatotic liver disease (MASLD).
- Effective management of liver fibrosis is essential due to its significant public health impact and high mortality rates.
- A comprehensive synthesis of existing preclinical and clinical research on liver fibrosis is currently lacking.
Purpose of the Study:
- To provide a systematic overview of liver fibrogenesis, covering etiological drivers, cellular mechanisms, signaling pathways, and extracellular matrix dynamics.
- To classify and analyze current and emerging therapeutic interventions for liver fibrosis, including etiological treatments and antifibrotic agents.
- To explore future therapeutic directions, emphasizing precision medicine, combination therapies, novel targets, and advanced drug delivery systems.
Main Methods:
- Systematic review of the molecular mechanisms underlying liver fibrogenesis.
- Classification of therapeutic interventions into etiological and mechanism-based antifibrotic approaches.
- Analysis of emerging strategies such as targeting the gut-liver axis, gut microbiota, and cell-based therapies.
Main Results:
- Detailed summary of the molecular panorama of liver fibrogenesis, including key cellular players and signaling pathways.
- Systematic classification of therapeutic interventions in preclinical and clinical stages.
- Identification of emerging strategies and future perspectives in liver fibrosis treatment.
Conclusions:
- This review offers a comprehensive understanding of liver fibrosis, from its causes and mechanisms to current and future therapeutic strategies.
- It highlights the importance of etiological treatments alongside mechanism-based antifibrotic therapies.
- Future directions emphasize precision medicine, combination therapies, and novel approaches for improved liver fibrosis management.
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