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Association Between Constipation and Frailty in Maintenance Hemodialysis Patients: A Cross-Sectional Study
Sheng Wu1, Ting Dong1, Peiyang Cao1
1Department of Nephrology, The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital), Suzhou, Jiangsu, People's Republic of China.
Journal of Multidisciplinary Healthcare
|November 27, 2025
Summary
Constipation is common in maintenance hemodialysis (MHD) patients and linked to frailty. Monitoring frailty in these patients is crucial for better outcomes.
Area of Science:
- Nephrology
- Geriatrics
- Gastroenterology
Background:
- Constipation and frailty are prevalent in maintenance hemodialysis (MHD) patients.
- Both conditions are associated with adverse clinical outcomes in this population.
Purpose of the Study:
- To investigate the relationship between constipation and frailty in patients undergoing maintenance hemodialysis.
- To identify specific frailty components associated with constipation in MHD patients.
Main Methods:
- Cross-sectional study of 207 MHD patients in China.
- Rome IV criteria for constipation and Fried Frailty Phenotype scale for frailty assessment.
- Multivariate logistic regression analysis to determine associations.
Main Results:
- 48.3% of MHD patients had constipation; 30.4% had frailty.
- Constipation was independently associated with frailty (OR: 7.61).
- Slow gait speed and low physical activity were independently associated with constipation.
Conclusions:
- Frailty is independently associated with constipation in MHD patients.
- Clinical monitoring of frailty is recommended for MHD patients experiencing constipation.
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