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Integrated Hydrogel Optical Fiber Electronics with Mechanically Robust Interfaces Enable Simultaneous

Xingmei Chen1, Lulu Wang2, Qingfang Duan1

  • 1Department of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen, 518055, China.

Advanced Materials (Deerfield Beach, Fla.)
|November 27, 2025
PubMed
Summary
This summary is machine-generated.

Researchers developed an integrated hydrogel optical fiber electronics (iHOFE) platform for neural bioelectronics. This device enables simultaneous electrical recording and optical modulation of neural circuits with high fidelity.

Keywords:
electricalhydrogel fibersinterfacemechanical robustnessoptical

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Area of Science:

  • Neural bioelectronics
  • Biomaterials science
  • Neuroscience engineering

Background:

  • Hydrogel-based electrodes and optical guides are key for neural bioelectronics due to their compliance and hydration.
  • Integrating multiple hydrogel functionalities in one device is difficult because of material compatibility and interfacial issues.

Purpose of the Study:

  • To develop an integrated hydrogel optical fiber electronics (iHOFE) platform.
  • To enable concurrent electrical and optical neural interfacing within a single device.

Main Methods:

  • Fabrication of a multilayer hydrogel structure with an optical core, conductive layer, and insulating sheath.
  • Engineering robust interfaces between hydrogel layers using chemical bonding and topological entanglement.
  • Testing the platform's performance through long-term (two-month) hippocampal implantation in vivo.

Main Results:

  • Demonstrated a stable, multilayer hydrogel device capable of concurrent electrical and optical operation under mechanical stress.
  • Achieved high-fidelity electrophysiological recording and optogenetic modulation in the same neural region.
  • Validated the platform's long-term efficacy and biocompatibility in vivo.

Conclusions:

  • The iHOFE platform successfully integrates electrical and optical functionalities for neural interfacing.
  • This technology advances the development of multifunctional neural bioelectronics for deep neural circuit interrogation and manipulation.
  • The engineered interfaces and material design overcome previous limitations in multimodal hydrogel device integration.