Angiogenesis in metastatic colorectal cancer: a bibliometric analysis of 5875 publications between 2000 and 2023

In order to better understand the trends and hot spots in angiogenesis research in metastatic colorectal cancer, this study uses bibliometric analysis to conduct a systematic analysis.

Publications were retrieved from Web of Science Core Collection from 2000 to 2023. All studies were output for further analysis in R and CiteSpace software.

A total of 5875 studies were recruited via the Web of Science Core Collection from 2000 to 2023 regarding the field of angiogenesis in metastatic colorectal cancer. China and USA were the leading country with top country publications. Among all contributed authors, the main three subjects were determined as cell biology, oncology, and peripheral vascular disease. Furthermore, network analysis of all recruited studies identified 16 research subjects. Next, the top 25 countries, authors references, institutions, and keywords with the strongest citation bursts were identified. To further delineate the growth and change of two types of keywords, Keywords Plus^® and author keywords, a heatmap analysis was employed. Last, the most influential references relating to this field were identified using the strongest citation bursts.

This study explored the research hot spots and trends of angiogenesis in metastatic colorectal cancer through bibliometric analysis. It would help researchers better understand the current status and future development hotspots of global research to promote further development in this field.