Related Experiment Video
Updated: Jan 10, 2026
09:48
Development of Organoids from Mouse Pituitary as In Vitro Model to Explore Pituitary Stem Cell Biology
Published on: February 25, 2022
4.5K
EndoCompass Project: Research Roadmap for Pituitary and Neuroendocrine Tumor Endocrinology
Justo P Castano1,2,3, Mehul Tulsidas Dattani4,5, Simona Grozinsky-Glasberg6
1Department of Cell Biology, Physiology, and Immunology, University of Córdoba, Córdoba, Spain.
Hormone Research in Paediatrics
|November 27, 2025
Summary
Endocrine research funding in the EU lags behind the impact of hormone disorders. The EndoCompass project identified key research priorities, including genetic factors and personalized treatments for endocrine diseases, to guide future investment.
Area of Science:
- Endocrinology and hormone health research.
- Neuroendocrine tumor and pituitary disease investigation.
Background:
- Endocrine science is underrepresented in EU research funding.
- A gap exists between the societal impact of endocrine disorders and research prioritization.
- The EndoCompass project aims to define strategic research priorities in endocrine science.
Purpose of the Study:
- To identify and promote strategic research priorities in endocrine science.
- To address critical hormone-related health challenges.
- To align research funding with areas of highest potential impact.
Main Methods:
- Analysis of the EU CORDIS database (Horizon 2020).
- Expert consultations in pituitary and neuroendocrine tumor endocrinology.
- Stakeholder engagement with society members and patient advocacy groups.
Main Results:
- Priorities include congenital/acquired disorders, tumor progression, and neuroendocrine neoplasms.
- Key areas: genetic/epigenetic factors, tumor microenvironment, AI, personalized treatments.
- Emphasis on aggressive tumors, hypothalamic syndromes, and pan-European biobanks.
Conclusions:
- Provides an evidence-based roadmap for strategic research investment in endocrinology.
- Identifies crucial areas for pituitary-neuroendocrine disease research (pathophysiology, prevention, treatment).
- Aims to reduce the burden of endocrine disorders on individuals and society.
More Related Videos
Related Concept Videos
01:28Preclinical Development: Overview
5.7K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
5.7K
01:45Endocrine Signaling
67.7K
Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
67.7K
02:07Tumor Progression
7.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.2K
01:27Hormones of the Pituitary Gland
9.2K
The small, pea-sized pituitary gland is located at the base of the brain. It is crucial in regulating various bodily functions, from growth to reproduction. The gland is divided into the anterior lobe and the posterior lobe. The secretory cell clusters in the pars distalis of the anterior pituitary lobe are controlled by hypothalamic regulators and synthesize six primary hormones.
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
The most abundantly secreted hormone from the anterior lobe is the growth hormone, which controls overall growth by...
9.2K
00:59Structures of the Endocrine System
11.4K
The intricate framework of the endocrine system encompasses a diverse array of glands, with their target tissues and organs strategically distributed throughout the body. Central to this network are the endocrine glands, specialized structures that lack ducts and release hormones directly into the interstitial fluid. Notably, the hypothalamus, a vital neuroendocrine organ situated in the brain, governs neural functions and serves as a potent source of hormonal regulation. Near the hypothalamus...
11.4K