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Shift work is associated with selective brain volume loss: a longitudinal study.

Thomas Welton1, Thomas Wei Jun Teo2, Seyed Ehsan Saffari3

  • 1Department of Research, National Neuroscience Institute, Singapore; Neuroscience and Behavioural Disorders, Duke-NUS Medical School, Singapore.

Neuroimage
|November 27, 2025
PubMed
Summary
This summary is machine-generated.

Shift work is linked to brain volume loss in the thalamus and amygdala. This brain volume loss stops within 2.4 years of ceasing shift work, suggesting interventions can protect the aging brain.

Keywords:
CognitionMagnetic resonance imagingOccupationalSleepWakefulness

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Area of Science:

  • Neuroscience
  • Occupational Health
  • Aging Research

Background:

  • Global work patterns are shifting towards increased shift work and later-life employment.
  • Shift work is associated with disrupted sleep, cognitive impairment, and increased risk of metabolic and neurodegenerative diseases, with aging exacerbating these effects.
  • The neural underpinnings of shift work's impact on the brain, particularly during aging, are not well understood.

Purpose of the Study:

  • To investigate the relationship between shift work and brain structure in healthy adults.
  • To examine how brain structure changes over time in older individuals who engage in shift work.

Main Methods:

  • Analysis of a population-based longitudinal cohort study including 14,198 participants.
  • Utilized brain MRI and self-report questionnaires on health, sleep, cognition, and employment.
  • Employed linear regression to compare 2,122 shift workers with 12,076 non-shift workers on 153 structural brain parameters, controlling for covariates.

Main Results:

  • Shift workers exhibited symmetrical volume loss in the right thalamus and left amygdala compared to non-shift workers.
  • Individuals who stopped shift work showed a cessation of this volume loss within 2.4 years.
  • Secondary analyses indicated microstructural degradation in specific white matter tracts and a negative correlation between volume loss and cognitive performance.

Conclusions:

  • Shift work is associated with selective brain volume loss in the thalamus and amygdala.
  • This volume loss is reversible or halts upon cessation of shift work within 2.4 years.
  • Monitoring, counseling, and work schedule adjustments may mitigate brain volume loss in shift workers.