The cross talk between protein misfolding and tumor microenvironment dynamics
M Sreejith1, Sonu Benny2, Vishnu V R2
1Nazerath College of Pharmacy, Pathanamthitta, Kerala, India.
Advances in Protein Chemistry and Structural Biology
|November 27, 2025
Summary
Protein misfolding causes cancer progression by altering the tumor microenvironment (TME). Understanding this interaction reveals new therapeutic strategies for cancer treatment.
Area of Science:
- Biochemistry
- Oncology
- Molecular Biology
Background:
- Protein misfolding leads to abnormal structures and impaired function.
- Misfolded proteins are implicated in various diseases, notably cancer.
- Cancer cells secrete misfolded proteins that interact with the tumor microenvironment (TME).
Purpose of the Study:
- To explore the molecular basis of protein misfolding.
- To elucidate the role of misfolded proteins in modulating the TME.
- To investigate the impact of protein misfolding on cancer progression and therapeutic strategies.
Main Methods:
- Literature review on protein misfolding and cancer.
- Analysis of molecular mechanisms linking misfolded proteins and TME.
- Examination of case studies in cancer treatment and research.
Main Results:
- Protein misfolding drives tumorigenesis by enhancing proliferation, metastasis, and chemoresistance.
- Misfolded proteins modulate the TME, influencing immune responses and oncogenic processes.
- Therapeutic strategies targeting protein misfolding show promise in cancer treatment.
Conclusions:
- Protein misfolding is a critical factor in cancer progression and TME modulation.
- Targeting misfolded proteins offers novel therapeutic avenues for cancer.
- Further research into protein misfolding and the TME is essential for advancing cancer therapies.
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