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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Genomic Imprinting and Inheritance02:30

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
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Combinatorial Gene Control02:33

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Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
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Regulation of Expression at Multiple Steps01:23

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The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
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Updated: Jan 10, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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Toward a logic-based framework for plant epigenetic control.

Lingrui Zhang1, Jian-Kang Zhu2

  • 1Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907, USA.

Trends in Plant Science
|November 27, 2025
PubMed
Summary
This summary is machine-generated.

Plant epigenome editing offers reversible trait control without DNA changes. Integrating epigenome editing with synthetic gene circuits enables programmable, context-aware regulation for scalable trait engineering.

Keywords:
CRISPRepigenome editinggene regulationgenome editingmacro-epigeneticssynthetic gene circuit

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Area of Science:

  • Plant biotechnology
  • Synthetic biology
  • Epigenetics

Background:

  • Genome editing is precise but irreversible, limiting its applications.
  • Current epigenome editing tools lack dynamic regulatory capabilities.
  • Plant trait regulation requires advanced, adaptable genetic control mechanisms.

Purpose of the Study:

  • To survey emerging plant epigenome editing technologies.
  • To explore integrating epigenome editing with logic-based synthetic gene circuits.
  • To propose novel strategies for programmable plant trait regulation.

Main Methods:

  • Review of current plant epigenome editing modalities.
  • Conceptual design of logic-gated synthetic gene circuits for plants.
  • Proposal of specific applications in Arabidopsis and Solanum lycopersicum.

Main Results:

  • Identification of plant-tailored epigenome editing approaches.
  • Design of multiplexer-driven flowering switches and Boolean logic-gated fruit ripening systems.
  • Development of roadmaps and mitigation strategies for plant epigenome engineering.

Conclusions:

  • Integrating epigenome editing with synthetic logic enables programmable, context-aware regulation.
  • Composite epigenome engineering offers scalable and predictive control of plant traits.
  • This approach transforms static genetic modification into dynamic, adaptive trait management.