Governing Synthetic Biology: A Co-Evolutionary Framework for Sustainable Innovation.

Area of Science:

• Synthetic biology
• Biotechnology
• Bioeconomy

Background:

• Synthetic biology has evolved from lab research to a key driver of biomanufacturing and industrial innovation.
• Technological progress in areas like gene editing and automation accelerates synthetic biology's industrial applications.
• Current regulatory frameworks and societal acceptance hinder the sustainable advancement of synthetic biology.

Purpose of the Study:

• To provide a chronological analysis of synthetic biology's development.
• To examine the regulatory and policy challenges impacting synthetic biology.
• To propose a co-evolutionary governance model for emerging technologies.

Main Methods:

• Chronological analysis of synthetic biology's evolution.
• Examination of regulatory and policy landscapes.
• Application of the OECD's Framework for Anticipatory Governance of Emerging Technologies.
• Identification of five key elements for co-evolution: R&D, strategic intelligence, societal trust, agile regulation, and international cooperation.

Main Results:

• Technological advancements are outpacing regulatory and societal adaptation in synthetic biology.
• A 'co-evolutionary' model is proposed, integrating technology development with institutional frameworks.
• Key elements for successful integration include research, intelligence, trust, regulation, and cooperation.

Conclusions:

• Sustainable advancement of synthetic biology requires aligning technological progress with societal and institutional frameworks.
• Policy support and scientists' consideration of societal context are crucial for transforming scientific innovation into societal value.
• A collaborative governance approach involving scientists, policymakers, and civil society is essential for the future of synthetic biology.