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Gut Microbiota Modulation by Lacticaseibacillus paracasei EFEL6501 Ameliorates Muscle Atrophy
Geum Na Pyeon1, Hyunbin Seong1, Jin Seok Moon2
1Brain Korea21 Center for Smart GreenBio Convergence and Sustainable Regional Development, Division of Animal, Horticultural, and Food Sciences, Chungbuk National University, Cheongju 28644, Republic of Korea.
Journal of Microbiology and Biotechnology
|November 27, 2025
Summary
Lacticaseibacillus paracasei EFEL6501 (EFEL6501) prevents muscle atrophy by improving muscle metabolism and gut health. This probiotic shows anti-atrophic effects in vitro and in vivo, enhancing muscle mass and strength.
Area of Science:
- Microbiology
- Muscle Physiology
- Gut Microbiome Research
Background:
- Probiotics modulate host health via gut microbiota and bioactive metabolites.
- Muscle atrophy is a significant health concern associated with muscle degradation and protein loss.
Purpose of the Study:
- To investigate the anti-atrophic effects of Lacticaseibacillus paracasei EFEL6501 (EFEL6501).
- To evaluate EFEL6501's impact on dexamethasone (DEX)-induced muscle atrophy in vitro and in vivo.
Main Methods:
- In vitro studies using DEX-treated C2C12 myotubes.
- In vivo studies involving EFEL6501 supplementation in a mouse model.
- Analysis of muscle parameters, protein synthesis/degradation pathways, and gut microbiota composition.
Main Results:
- EFEL6501 metabolites alleviated muscle degradation and restored protein synthesis in vitro.
- EFEL6501 supplementation increased muscle thickness, grip strength, and muscle fiber CSA in mice.
- EFEL6501 modulated gut microbiota, increasing beneficial bacteria and acetate levels, while suppressing protein degradation.
Conclusions:
- EFEL6501 demonstrates significant anti-atrophic effects by regulating muscle metabolism.
- EFEL6501 positively influences gut microbiota composition and function.
- EFEL6501 shows potential as a functional probiotic for preventing muscle atrophy.
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