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Isolation, Processing and Analysis of Murine Gingival Cells
Published on: July 2, 2013
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Shared Inflammatory Mechanisms in Psoriasis and Periodontitis: A Cross-Sectional Study
Zhala Vatankha Sain1, Ozlem Daltaban1, Cahit Kacar2
1Department of Periodontology, Akdeniz University, Faculty of Dentistry, Antalya, Turkey.
Oral Diseases
|November 27, 2025
Summary
Psoriasis may worsen periodontal disease by increasing inflammatory markers like TNF-α and IL-17A in the gums and blood. This study highlights the link between these chronic inflammatory conditions.
Area of Science:
- Immunology
- Periodontology
- Dermatology
Background:
- Psoriasis and periodontitis are chronic inflammatory diseases linked to immune dysregulation.
- Investigating the association between these conditions is crucial for understanding shared inflammatory pathways.
Purpose of the Study:
- To evaluate periodontal parameters and inflammatory markers (TNF-α, IL-17A, YKL-40) in gingival crevicular fluid (GCF) and serum.
- To explore the relationship between psoriasis and periodontitis.
Main Methods:
- Sixty participants were categorized into healthy controls, periodontitis, and psoriasis with periodontitis groups.
- Periodontal indices (PI, BOP, PD, CAL) were assessed.
- Concentrations of TNF-α, IL-17A, and YKL-40 in GCF and serum were measured using ELISA.
Main Results:
- Periodontal parameters were significantly worse in both periodontitis groups compared to controls.
- Serum TNF-α and IL-17A were highest in the psoriasis with periodontitis group.
- GCF TNF-α and serum/GCF YKL-40 were elevated in periodontitis groups; GCF IL-17A was elevated in the periodontitis-only group.
Conclusions:
- Psoriasis may influence the severity of periodontal inflammation.
- Elevated inflammatory markers suggest a potential link between systemic inflammation in psoriasis and local inflammation in periodontitis.
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