New indole diketopiperazine from the fungus Penicillium chrysogenum
Minhui Ji1,2, Qianqian Liu1, Ling Liu3,4
1State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China.
Abstract:
A new indole diketopiperazine penichrysogenone A (1), and two new natural products 4-(N-benzoyl-N-hydroxyamino)-butyric acid (2) and 2-acetamido-N-benzyl-2-(ethylamino)acetamide (3), together with 10 known compounds (4-13) were isolated from the fungus Penicillium chrysogenum wis54-1255. The structure of new compound was determined by the extensive spectroscopic analyses and ECD calculations. Bioactivity assays revealed that compound 4 showed antibacterial activity against Pseudomonas solanacearum (MIC = 64 μg/mL), while compound 10 exhibited antifungal activity against Candida auris (MIC = 32 μg/mL). Furthermore, compounds 2 and 10 displayed potent ABTS radical scavenging activity, superior to that of the positive control ascorbic acid.
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