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Updated: Jan 10, 2026
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Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy
Published on: April 9, 2019
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Micro-ultrasound for prostate cancer
Melis Guer1,2, Wayne G Brisbane3, Hannes Cash4
1Division of Urology, Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.
Nature Reviews. Urology
|November 27, 2025
Summary
Micro-ultrasound (microUS) offers a cost-effective alternative for prostate cancer detection, showing non-inferiority to MRI for detecting significant cancers in biopsy-naive men. Further research and AI integration may optimize its use.
Area of Science:
- Urology
- Medical Imaging
- Oncology
Background:
- Prostate cancer diagnostics rely heavily on MRI, but its high cost and limited access necessitate alternatives.
- Advancements in imaging and biopsy techniques are crucial for evolving prostate cancer detection workflows.
Purpose of the Study:
- To evaluate micro-ultrasound (microUS) as a cost- and time-effective alternative to MRI for prostate cancer detection.
- To assess the efficacy of microUS in identifying Grade Group ≥2 prostate cancer in biopsy-naive men.
Main Methods:
- Comparison of micro-ultrasound (microUS) with MRI for prostate cancer detection.
- Utilizing microUS with 70-micron resolution to image prostatic ductal anatomy.
- Analysis of Level 1 evidence comparing microUS and MRI outcomes.
Main Results:
- Micro-ultrasound (microUS) demonstrates non-inferiority to MRI in detecting Grade Group ≥2 prostate cancer.
- MicroUS provides high-resolution imaging of prostatic ductal anatomy, offering a viable alternative modality.
Conclusions:
- Micro-ultrasound (microUS) is a promising, cost-effective imaging tool for prostate cancer detection, comparable to MRI.
- Future research and AI integration are needed to optimize microUS performance and reduce inter-reader variability.
