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Red single wavelength emitting up-conversion nanoparticles modulate cellular dynamics and gene expression in T24
Asmaa R Alsayeh1, E M Abdelrazek1, A H Oraby1
1Department of Physics, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt.
Scientific Reports
|November 27, 2025
Summary
Red upconversion nanoparticles (UCNPs) show promise for treating bladder cancer by inducing cell death and inhibiting repair. These nanoparticles, when combined with radiation, offer enhanced therapeutic effects.
Area of Science:
- Nanotechnology
- Biomedical Engineering
- Oncology
Background:
- Bladder cancer presents a significant global health challenge, necessitating novel therapeutic approaches.
- Current treatments have limitations, driving research into advanced strategies like nanomedicine.
Purpose of the Study:
- To investigate the therapeutic potential of red single-wavelength upconversion nanoparticles (UCNPs) co-doped with Sm³⁺ and Nd³⁺ on T24 bladder cancer cells.
- To evaluate the combined effects of UCNPs and near-infrared (NIR) radiation on cancer cell viability and progression.
Main Methods:
- Synthesis and characterization of Sm³⁺/Nd³⁺ co-doped NaYbF₄ UCNPs.
- In vitro evaluation of UCNP cytotoxicity, wound healing inhibition, and gene expression modulation in T24 cells.
- Assessment of reactive oxygen species (ROS) generation and effects of NIR radiation.
Main Results:
- UCNPs exhibited strong red emission under 980 nm NIR excitation.
- Concentration-dependent cytotoxicity and inhibition of cellular repair were observed, enhanced by radiation.
- UCNPs modulated key cancer-related genes (e.g., IL-6, BCL2, HIF, Survivin) and induced oxidative stress via ROS generation.
Conclusions:
- Sm³⁺/Nd³⁺ co-doped UCNPs demonstrate significant therapeutic potential against bladder cancer cells.
- The combination of UCNPs and NIR radiation offers an enhanced strategy for bladder cancer treatment.
- UCNPs represent a promising nanomedicine platform for targeting and treating bladder cancer.
