Multifunctional Fe-Doped MOF-808 Nanocomposites for Chemo/Chemodynamic Synergistic Therapy

Theranostic nanomedicines combining targeted drug delivery and emerging therapeutic modalities with diagnosis are a rapidly evolving field in cancer therapy. In addition to conventional drug delivery, metal-organic frameworks (MOFs), consisting of metal ions/clusters and multitopic organic ligands, have been recently highlighted as ideal candidates for chemodynamic therapy (CDT) where active metal ions can be integrated at inorganic secondary building units or coordinated to linkers to act as CDT catalysts. Metal doping provides a potential approach to endow archetypal MOFs with enhanced CDT efficacy; herein, a novel PEGylated Fe-doped MOF-808 is reported, which is embedded with ultrasmall gold nanoparticles and manganese ions, can deliver carboplatin (CA) and achieve chemotherapeutic-chemodynamic (CT/CDT) synergistic therapy. 2D and 3D in vitro experiments demonstrate the synergistic therapeutic efficacy of CT and CDT, while the nanocomposite also shows magnetic resonance imaging potential. Therefore, this work provides a novel protocol to construct multi-metal doped MOFs as promising candidates in diagnostic and multimodal therapeutic applications.