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Reduced Kidney Function and Left Atrial Dilatation as Predictors of Incident Atrial Fibrillation in Patients With

Yuriko Tsumaya1, Kenshi Hayashi2,3, Toyonobu Tsuda2

  • 1Department of Clinical Laboratory Kanazawa University Hospital Kanazawa Japan.

Journal of Arrhythmia
|November 28, 2025
PubMed

Insights

Reduced kidney function and larger left atrial size predict new-onset atrial fibrillation (AF) in hypertrophic cardiomyopathy (HCM) patients. Early detection and monitoring are crucial for this high-risk group.

Area of Science:

  • Cardiology
  • Nephrology
  • Clinical Research

Background:

  • Atrial fibrillation (AF) is common in hypertrophic cardiomyopathy (HCM), increasing risks.
  • Chronic kidney disease (CKD) is a cardiovascular risk factor, but its link to new-onset AF in HCM is unclear.
  • Estimated glomerular filtration rate (eGFR) is a key indicator of kidney function.

Purpose of the Study:

  • To determine the incidence of new-onset AF in HCM patients.
  • To identify predictors of new-onset AF, focusing on kidney function and left atrial size.

Main Methods:

  • 198 HCM patients without prior AF were analyzed.
  • Kidney function (eGFR) and left atrial diameter (LAD) were assessed.
  • Cox proportional hazards modeling identified predictors of AF.

Main Results:

  • 17.7% of patients had impaired kidney function (eGFR < 60).
  • Over 7.5 years, 21.7% developed new-onset AF (incidence 2.8/100 person-years).
  • Reduced eGFR and increased LAD were independent predictors of AF.

Conclusions:

  • Decreased kidney function and left atrial enlargement are linked to new-onset AF in HCM.
  • HCM patients need closer monitoring for AF detection.
  • Identifying these risk factors aids in managing AF risk in HCM.
Abstract

Keywords:
atrial fibrillationchronic kidney diseaseestimated glomerular filtration ratehypertrophic cardiomyopathyprediction

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