Related Experiment Video
Updated: Jan 10, 2026
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Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
Published on: April 14, 2014
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Retinal ganglion cell loss is associated with multimodal visual dysfunction following demyelinating optic neuritis
Mustafa Subhi1,2, Sargis Manukyan1,2,3, Gabriela Zabala1,2
1Visual Outcomes Laboratory, Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Multiple Sclerosis Journal - Experimental, Translational and Clinical
|November 28, 2025
Summary
Inter-eye differences in ganglion cell-inner plexiform layer (GCIPL) thickness effectively identify vision problems after optic neuritis (ON). These GCIPL thresholds offer a more accurate assessment of visual dysfunction in multiple sclerosis and related disorders.
Area of Science:
- Ophthalmology
- Neuroscience
- Medical Imaging
Background:
- Optic neuritis (ON) is a key manifestation of multiple sclerosis and related disorders (MSRD), causing retinal neurodegeneration like ganglion cell-inner plexiform layer (GCIPL) thinning.
- Inter-eye differences (IED) are crucial for assessing ON effects, accounting for individual baseline variations.
Purpose of the Study:
- To establish thresholds for retinal layer inter-eye differences (IED) that correlate with multimodal visual dysfunction following unilateral demyelinating optic neuritis (ON).
Main Methods:
- A cross-sectional study involving MSRD participants (with and without ON history) and healthy controls.
- Utilized optical coherence tomography (OCT), best-corrected visual acuity, low-contrast letter acuity (LCLA), standard automated perimetry, and color vision testing.
Main Results:
- Specific GCIPL IED thresholds were significantly associated with visual dysfunctions: 6.5% for dyschromatopsia, 11% for 1.25% LCLA, 13% for 2.5% LCLA, 15% for visual field mean depth (VFMD), and 27% for logarithm of minimum angle of resolution (logMAR).
- These GCIPL IED associations demonstrated higher robustness compared to other retinal layer IEDs.
Conclusions:
- Ganglion cell-inner plexiform layer (GCIPL) inter-eye difference (IED) thresholds provide a more precise reflection of multimodal visual dysfunction post-optic neuritis (ON).
- This highlights the clinical utility of GCIPL IED measurements in managing MSRD patients.
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