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Chirality in Nature02:30

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Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
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Chirality Enhanced Triplet-State Generation in a DNA-Intercalated Natural Antibiotic.

Lina Wang1, Lianxin Wang1, Xueli Wang1

  • 1State Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai 200241, China.

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|November 28, 2025
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Chiral DNA assemblies significantly boost triplet generation in intercalated molecules like gilvocarcin V. This study reveals how amplified excited-state chirality drives enhanced intersystem crossing for improved phototherapeutics and optoelectronics.

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Area of Science:

  • Photophysics and Chirality
  • Molecular Assemblies
  • Spectroscopy

Background:

  • Chiral assemblies influence photophysical processes, enhancing triplet generation in intercalated chromophores.
  • Applications span phototherapeutics and chiral optoelectronics.
  • The mechanism of chirality-enhanced intersystem crossing (ISC) is not fully understood.

Purpose of the Study:

  • To directly correlate the chiral gradient of DNA assemblies with enhanced ISC kinetics.
  • To elucidate the mechanism of excited-state chirality's effect on triplet-state generation.
  • To offer a design principle for high-performance triplet sensitizers.

Main Methods:

  • Femtosecond time-resolved circularly polarized luminescence (fs-TRCPL) spectroscopy.
  • Transient absorption (TA) spectroscopy.
  • Quantum chemical calculations.

Main Results:

  • A natural antibiotic, gilvocarcin V (GV), showed a significant increase in triplet quantum yield when intercalated into a DNA duplex (7.6% to 25.8%).
  • This enhancement is attributed to amplified excited-state chirality of GV.
  • Simultaneous ISC occurs from the Franck-Condon region and a charge-transfer state.

Conclusions:

  • Directly links chiral gradients in DNA assemblies to enhanced ISC kinetics.
  • Elucidates the role of excited-state chirality in triplet generation.
  • Provides a novel strategy for designing efficient triplet sensitizers using chiral assemblies.