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Updated: Jan 10, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Published on: February 7, 2019

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Helicene-Based Chiral Macrocycles and Molecular Cages: Synthetic Strategies, Chiroptical Modulation, and Emerging

Zewei Qi1, Jianjian Zhao1, Leyong Zhou1

  • 1State Key Laboratory of Petroleum Molecular & Process Engineering, Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Shanghai Frontiers Science Center of Molecule Intelligent Syntheses, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|November 28, 2025
PubMed
Summary

Helicene-based macrocycles and molecular cages offer tunable, enzyme-like cavities for advanced applications. This review details their synthesis, chiroptical properties, and potential in chiral functional materials.

Keywords:
cagechiroptical materialshelicenemacrocyclesupramolecular chemistry

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