Related Experiment Video For Cryptosporidium, colorectal cancer
Updated: Jan 10, 2026
Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
Published on: June 8, 2020
Elevated Interleukin-1β and Deep Tissue Cryptosporidium Infection in Colorectal Cancer: A Novel Association
Sri W Handayani1,2, Nuzulia Irawati1,3, Djong H Tjong1,4
1Doctoral Program in Biomedical Sciences, Faculty of Medicine, Andalas University, Padang, Indonesia.
Objective:
This research aimed to investigate the increase in the pro-inflammatory cytokines interleukin -1β, associated with colorectal cancer and Cryptosporidium spp.
Methods:
A total of 34 patients diagnosed with colorectal cancer were investigated at various stages. Fecal, blood, and tissue paraffin-block samples were collected from each patient. Furthermore, modified Ziehl-Neelsen staining, enzyme-linked immunosorbent assay (ELISA), and immunohistochemical staining were performed. Statistical tests were performed using the Kruskal-Wallis, Mann-Whitney, and Chi-Square tests.
Results:
Cryptosporidium spp. infection was found in 47.06% of patients with colorectal cancer. Cryptosporidium spp. spread throughout colorectal cancer tissue from the epithelium to the serous layer. Endogenous stages of Cryptosporidium spp. were observed within the submucosa, including its presence in the vascular submucosal region. Statistical tests showed no association between Cryptosporidium spp. infection with IL-1β levels (p > 0.05) due to heterogeneous data.
Conclusion:
This research strengthens the association between Cryptosporidium spp. infection and colorectal cancer, with new evidence regarding active, chronic, invasive, and potentially extraintestinal infection. However, there is a trend of increasing serum levels of IL-1β in colorectal cancer patients infected with Cryptosporidium spp. compared to those who are uninfected individuals. These results provide a basis for further investigation into alternative pathogenic mechanisms by which the parasite may contribute to colorectal carcinogenesis independently or with various inflammatory pathways.
More Related Videos
Related Concept Videos
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...