Related Experiment Video
Updated: Jan 10, 2026

Using Primary Neurosphere Cultures to Study Primary Cilia
Published on: April 14, 2017
[The primary cilium: a key signaling antenna for muscle stem cell function]
Anna Rausch de Traubenberg1, Caroline E Brun1
1Institut NeuroMyoGène - Physiopathologie et Génétique du Neurone et du Muscle (INMG-PGNM), CNRS UMR5261, Inserm U1315, Université Claude Bernard Lyon 1, Lyon, France.
Abstract:
Muscle stem cells are the gatekeepers of skeletal muscle integrity throughout life. They ensure muscle regeneration in case of a tissue injury. This process requires a precise reception of the environmental cues and an adequate cellular response from these specialized progenitor cells. They possess a primary cilium, a cellular antenna dedicated for reception and transduction of environmental signals. Several recent studies show that this organelle actively mediates signaling required for muscle stem cell quiescence maintenance, proliferation and fate. Here, we review the latest advances that revealed the role of the primary cilium in regulating the function of these muscle-resident stem cells.
More Related Videos
Related Concept Videos
Microtubules in Signaling
Satellite Stem Cells and Muscular Dystrophy
Cell Motility through Blebbing
Blebbing Through the Matrix
In multicellular...
Cytoskeletal Coordination in Cell Migration
Calmodulin-dependent Signaling
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
Assembly of Complex Microtubule Structures

