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Updated: Jan 10, 2026

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
Published on: January 26, 2018
[Protein lysine demethylation regulates metabolic reprogramming during muscle stem cells fate]
Delia Cicciarello1, Isabella Scionti1
1Pathophysiology and Genetics of Neuron and Muscle (PGNM), Institut NeuroMyoGène, Université Claude Bernard Lyon 1, CNRS UMR5261, Inserm U1315, Faculté de Médecine Rockefeller, France.
Abstract:
Muscle regeneration in response to injury is a fine regulated process which relies on the ability of resident muscle stem cells (MuSCs) to activate, proliferate and differentiate to repair the injured myofibers. Muscle stem cells fate and correct skeletal muscle regeneration upon injury is guaranteed by a finely controlled crosstalk between transcriptional, epigenetic and metabolic regulation. Here, we explore the tight connection between cellular metabolism and epigenetic regulation during muscle stem cells fate focusing our attention on lysine demethylase enzymes.
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