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Updated: Jan 10, 2026
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Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood
Published on: October 2, 2019
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Polysomnography and Autonomic Function Signatures of Nocturnal Enuresis: An Observational Study
Parag Thosare1, Biswaroop Chakrabarty2, Sheffali Gulati3
1Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
Pediatric Neurology
|November 28, 2025
Summary
Primary monosymptomatic nocturnal enuresis (PMNE) often involves impaired sleep and behavioral issues. Concurrent sleep disorders, especially sleep-related movement disorder (SRMD), predict poor response to standard behavioral therapy for PMNE.
Area of Science:
- Pediatric Sleep Medicine
- Autonomic Neurology
- Behavioral Pediatrics
Background:
- Primary monosymptomatic nocturnal enuresis (PMNE) evaluation has yielded inconsistent results.
- Simultaneous assessment of polysomnography and autonomic function is needed for better understanding and treatment of PMNE.
Purpose of the Study:
- To concurrently evaluate overnight polysomnography and autonomic function in children with PMNE.
- To elucidate the pathophysiology of PMNE and identify factors influencing treatment response.
Main Methods:
- Children aged 5-18 with PMNE underwent overnight polysomnography and autonomic function testing.
- Psychological assessments included sleep evaluation, behavior checklists, and personality testing.
- Participants received 12 weeks of standard behavioral therapy.
Main Results:
- 71.4% of PMNE cases had sleep-related breathing disorders and 61.9% had sleep-related movement disorders (SRMD).
- PMNE patients exhibited lower sleep efficiency and altered sleep stage distribution compared to controls.
- Autonomic function showed minimal diurnal sympathetic variation; SRMD was linked to poor therapy response.
Conclusions:
- PMNE may involve dopamine depletion, particularly in patients with sleep disturbances and SRMD.
- Impaired sleep and SRMD are significant factors affecting treatment outcomes in PMNE.
- Findings suggest potential therapeutic implications for dopamine modulation in specific PMNE cases.
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