IMMUNOLOGICAL CRITERIA FOR PREDICTING SEVERE AND COMPLICATED FORMS OF VARICELLA ZOSTER IN CHILDREN
Z Alshimbayeva1, R Begaydarova1, N Khodzhaeva2
11NJSC "Karaganda Medical University", Kazakhstan.
Insights
Elevated C-reactive protein (CRP), C3, and platelets, along with decreased C4, predict severe varicella zoster virus (VZ) in children. These immunological markers aid in early risk identification for better treatment.
Area of Science:
- Pediatric Infectious Diseases
- Immunology
- Clinical Diagnostics
Background:
- Varicella zoster virus (VZ) can lead to severe and complicated forms in children.
- Identifying prognostic criteria for disease severity is crucial for timely intervention.
Purpose of the Study:
- To evaluate immunological markers for predicting severe and complicated varicella in children.
- To establish prognostic criteria for VZ disease severity.
Main Methods:
- 120 children with VZ were studied, divided into complicated (n=63) and uncomplicated (n=57) groups.
- Assessed interferon alpha, complement components (C3, C4), anti-MAG/TGF antibodies, complete blood count, and C-reactive protein (CRP).
- Utilized binary logistic regression and 5-fold cross-validation for statistical analysis.
Main Results:
- Significant predictors of complicated VZ included elevated CRP (OR=10.05), platelets (OR=9.69), and C3 (OR=2.77).
- Reduced C4 levels (OR=0.036) were also associated with complicated disease.
- The logistic regression model demonstrated strong discriminatory ability (AUC=0.7857).
Conclusions:
- CRP, C3, C4, and platelet levels serve as valuable prognostic markers for complicated varicella in children.
- Early assessment of immune status aids in identifying at-risk patients.
- Optimizing treatment tactics is facilitated by timely risk identification.
Aim Of The Study:
To evaluate immunological markers associated with the risk of severe and complicated forms of varicella zoster virus (VZ) in children in order to determine prognostic criteria for disease severity.
Materials And Methods:
The study included 120 children with VZ, divided into groups with complicated (n=63) and uncomplicated (n=57) disease. All patients underwent assessment of interferon alpha markers, complement components (C3, C4), antibodies to MAG, TGF, as well as analysis of complete blood count and C-reactive protein (CRP). Statistical analysis included binary logistic regression and 5-fold cross-validation.
Selection Criteria:
Children aged 0 to 18 years inclusive with a verified diagnosis of varicella Results: The most significant predictors of complicated disease were elevated levels of CRP (OR=10.05; p<0.001), platelets (OR=9.69; p=0.04), and C3 component (OR=2.77; p=0.006), as well as reduced levels of C4 component (OR=0.036; p=0.005). The logistic regression model showed high discriminatory ability (AUC=0.7857).
Conclusion:
Immunological parameters such as CRP, C3, C4 and platelets can be used as prognostic markers of complicated varicella in children. Early assessment of immune status contributes to the timely identification of patients at risk and optimization of treatment tactics.
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