Related Experiment Video

Updated: Feb 10, 2026

Biochemical Measurement of Neonatal Hypoxia
13:13

Biochemical Measurement of Neonatal Hypoxia

Published on: August 24, 2011

14.4K

Biochemical markers of hypertension, prehypertension

L Turgunova1, B Koichubekov1, A Turmuhambetova1

  • 1Karaganda State Medical University, 40, Gogol Street, 100008 Karaganda, Kazakhstan.

Annales De Cardiologie Et D'Angeiologie
|May 23, 2018
PubMed

Insights

Biochemical markers indicate endothelial dysfunction and target organ damage in prehypertension and hypertension. These markers, including LIGHT and Endocan, are elevated, especially in hypertension.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Clinical Research

Background:

  • Hypertension and prehypertension lack sufficient research on biochemical markers for disease mechanisms and target organ damage.
  • Endothelial dysfunction and cardiovascular system damage are critical aspects of hypertension and prehypertension.

Purpose of the Study:

  • To investigate biochemical markers of endothelial dysfunction and cardiovascular damage in individuals with hypertension and prehypertension.
  • To evaluate the levels of specific inflammatory and apoptosis markers in different blood pressure groups.

Main Methods:

  • A cross-sectional study involving 938 participants aged 18-65.
  • Measurement of blood pressure, glucose, cholesterol, and concentrations of interleukin-6, sFAS, LIGHT, hFABP, NT-ProBNP, and Endocan.
  • Classification of participants into normotension, prehypertension, and hypertension groups based on blood pressure levels.

Main Results:

  • The prehypertension group showed elevated levels of LIGHT and Endocan compared to the control group.
  • The hypertension group exhibited increased levels of LIGHT, Endocan, and heart-type fatty-acid-binding protein (hFABP) compared to the control group.
  • These findings suggest a correlation between elevated biochemical markers and the progression of hypertension.

Conclusions:

  • The development of prehypertension and hypertension is associated with increased activity of biochemical markers for endothelial dysfunction and target organ damage.
  • The observed marker elevations are more pronounced in individuals with established hypertension compared to those with prehypertension.
  • These biochemical markers may serve as indicators for early detection and monitoring of cardiovascular risk in hypertensive and prehypertensive individuals.
Abstract

Keywords:
Atteinte cardiovasculaireBiochemical markersCardiovascular damageDysfonction endothélialeEndothelial dysfunctionHypertensionMarqueurs biochimiques

More Related Videos

Biochemical Titration of Glycogen In vitro07:16

Biochemical Titration of Glycogen In vitro

Published on: November 24, 2013

28.9K
Collecting And Measuring Wound Exudate Biochemical Mediators In Surgical Wounds04:58

Collecting And Measuring Wound Exudate Biochemical Mediators In Surgical Wounds

Published on: October 20, 2012

12.4K

Related Concept Videos

Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
940
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
990
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
472
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
4.5K
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
664
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
602