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Valuing Child Health: An EQ-5D-Y-3L Value Set for the United States
A Simon Pickard1, Jonathan L Nazari2, Juan M Ramos-Goñi3
1Department of Pharmacy Systems, Outcomes, and Policy, College of Pharmacy, University of Illinois Chicago, Chicago, Illinois, USA; Maths in Health B.V., Klimmen, The Netherlands.
Summary
A new US value set for the EQ-5D-Y-3L was developed using adult and adolescent preferences. This tool measures pediatric health-related quality of life, incorporating stakeholder input for value-based assessments.
Area of Science:
- Health Economics
- Psychometrics
- Pediatric Health Outcomes
Background:
- Measuring pediatric health-related quality of life (HRQoL) is crucial for evaluating healthcare interventions.
- Existing value sets may not fully capture the preferences of the US pediatric population.
- Stakeholder engagement is vital for developing relevant health outcome measures.
Purpose of the Study:
- To develop a United States EuroQol 5-Dimension Youth version, 3-Level (EQ-5D-Y-3L) value set.
- To measure pediatric HRQoL based on preferences from US adults and adolescents.
- To inform value-based assessments of medical interventions for children.
Main Methods:
- Utilized the EuroQol international valuation protocol with US stakeholder recommendations.
- Collected data via online discrete choice experiments (DCE) from US adults and adolescents (11-17 years).
- Adults also completed composite time trade-off (cTTO) tasks; DCE data were weighted for US population demographics and analyzed using mixed-logit models.
Main Results:
- The analytic sample included DCE data from 714 adolescents and 1669 adults, with cTTO data from 199 adults.
- Estimated utilities ranged from 0.079 (worst state) to 0.976 (best state).
- Pain/discomfort and emotional distress (worried/sad/unhappy) were identified as the most impactful dimensions.
Conclusions:
- The developed US EQ-5D-Y-3L value set addresses a critical need for pediatric HRQoL assessment.
- The value set incorporates preferences from both adolescents and adults, enhancing its applicability.
- Informed by US stakeholder engagement, this tool supports value-based decision-making in pediatric healthcare.
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