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Response to: "Refining Surgical Indications for Hepatocellular Carcinoma in Patients with Clinically Significant

Yukihiro Watanabe1, Masayasu Aikawa2, Yoshiki Murase2

  • 1Department of Gastroenterological Surgery, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama, 350-1298, Japan. watanb@saitama-med.ac.jp.

Hepatology International
|November 28, 2025
PubMed
Abstract

No abstract available in PubMed .

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Portal hypertension is an increase in blood pressure within the portal venous system. Normally, this pressure is less than 5 mmHg. It is considered clinically significant when it rises above 10 mmHg. At this threshold, complications from altered blood flow and venous congestion emerge.EtiologyPortal hypertension arises from conditions that impede blood flow through the liver. The most common cause is cirrhosis, in which chronic liver injury leads to fibrotic scarring. This fibrosis narrows or...

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