Related Experiment Video
Updated: Jan 10, 2026
Laparoscopic Left Hemihepatectomy Combined with Caudate Lobe Resection
Published on: April 11, 2025
Clinical outcomes after laparoscopic left hemihepatectomy with and without biliary duct exploration
Zhen Wan1, Lei Wu1, Xiang Liu2
1Department of General Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, 33006, China.
Background:
The operative procedures of laparoscopic left hemihepatectomy (LLH) with and without common bile duct (CBD) exploration are largely different. However, the two procedures are frequently included in the same category. The present study aimed to evaluate the impact of CBD exploration on clinical outcome in patients undergoing LLH, especially postoperative liver function and biliary leakage.
Methods:
The retrospective study included patients with left-sided intrahepatic bile duct stones at the First Affiliated Hospital of Nanchang University from January 2020 to June 2024. Patients were divided into simple LLH group and LLH with CBD exploration (LLHCBDE) group. Perioperative outcomes and stone recurrence between the two groups were evaluated. Moreover, we performed multivariable linear regression to analyze peak postoperative levels of alanine transaminase (ALT) and aspartate transaminase (AST) and logistic regression to analyze the occurrence of biliary leakage.
Results:
This study enrolled 176 patients, with 36 and 140 patients in the LLH and LLHCBDE groups, respectively. The LLHCBDE group demonstrated significantly longer operation time, longer hospital stays, higher peak postoperative transaminase levels, and a higher stone recurrence rate compared to the LLH group. However, there were no significant differences in the peak postoperative values of t-Bil and PT-INR, incidence of major complications or biliary leakage between the two groups. Multivariate stepwise linear regression analysis revealed that CBD exploration was an independent predictor of peak postoperative levels of alanine transaminase (β = 0.313, P < 0.001) and aspartate transaminase (β = 0.359, P < 0.001). Furthermore, period of less than 1 month between LLH and the latest episode of acute cholangitis (OR 4.362, 95%CI 1.126-16.904, P = 0.033) and intraoperative blood loss (OR 1.022, 95%CI 1.013-1.031, P < 0.001) were independent risk factors for postoperative biliary leakage.
Conclusions:
Despite conferring a distinct clinical profile characterized by slower recovery, a higher rate of stone recurrence and higher peak postoperative transaminase levels, the addition of CBD exploration to LLH did not impair functional hepatic regeneration or increase the risk of biliary leakage.
