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Evaluating the predictive value of the CALLY index for MACE events in STEMI patients: a comparative analysis across

Dongxia Xu1,2,3, Yehong Liu3, Jiangping Ye1,2,3

  • 1Wuxi Clinical College of Anhui Medical University, Wuxi, Jiangsu, People's Republic of China.

Journal of Cardiothoracic Surgery
|November 29, 2025
PubMed

Insights

The C-reactive protein-albumin-lymphocyte (CALLY) index, measured 24 hours after percutaneous coronary intervention (PCI), effectively predicts long-term major adverse cardiovascular events (MACEs) in ST-segment elevation myocardial infarction (STEMI) patients. This index also correlates with coronary disease severity and reperfusion success.

Area of Science:

  • Cardiology
  • Biomarkers
  • Predictive Analytics

Background:

  • ST-segment elevation myocardial infarction (STEMI) poses significant mortality and morbidity risks.
  • Reliable predictive instruments are crucial for managing STEMI patients post-percutaneous coronary intervention (PCI).
  • The C-reactive protein-albumin-lymphocyte (CALLY) index is a potential prognostic marker.

Purpose of the Study:

  • To evaluate the predictive capability of the CALLY index at various time points for long-term STEMI prognosis after PCI.
  • To determine the optimal timing for CALLY index assessment in predicting major adverse cardiovascular events (MACEs).

Main Methods:

  • Retrospective analysis of 421 STEMI patients undergoing PCI.
  • CALLY index measurements at admission, 12-48 hours post-PCI, and at discharge.
  • Utilized Cox proportional hazard models, ROC curves, and Kaplan-Meier analysis to assess CALLY index predictive value for MACEs.

Main Results:

  • High CALLY index levels at 24 hours post-PCI (threshold=0.77) independently predicted lower long-term MACEs (HR=0.303, P<0.001).
  • The CALLY index at 24 hours post-PCI demonstrated the highest accuracy in predicting MACEs (AUC=0.712, P<0.001).
  • The 24-hour post-PCI CALLY index correlated significantly with no-reflow phenomenon (P=0.006) and Gensini score (P<0.001).

Conclusions:

  • The CALLY index measured 24 hours post-PCI is a valuable independent predictor of long-term MACEs in STEMI patients.
  • The CALLY index at 24 hours post-PCI shows strong predictive accuracy for adverse cardiovascular outcomes.
  • This index reflects coronary disease severity and reperfusion quality, aiding in STEMI patient risk stratification.
Abstract

Keywords:
Major adverse cardiovascular eventsPercutaneous coronary interventionPrognosisST-segment elevation myocardial infarctionThe c-reactive protein-albumin-lymphocyte index

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