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Related Experiment Video

Updated: Jan 9, 2026

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Published on: February 6, 2021

Pathogen-Associated Visual Outcomes Following Postprocedure Endophthalmitis.

Marusha Ather¹, Elizabeth Lyden², Yue Zhan²

¹From the University of Nebraska Medical Center (M.A.), Omaha, Nebraska, USA.

American Journal of Ophthalmology

|November 29, 2025

Summary

This summary is machine-generated.

Virulent bacteria like Streptococcus cause worse outcomes in postprocedure endophthalmitis. Early identification of these pathogens is crucial for better visual results and fewer complications.

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Area of Science:

Ophthalmology
Infectious Diseases

Background:

Postprocedure acute endophthalmitis is a serious complication following intraocular procedures.
Pathogen virulence is a key factor influencing patient outcomes.

Purpose of the Study:

To analyze anatomic and functional outcomes in postprocedure acute endophthalmitis.
To stratify outcomes based on pathogen virulence using a large, multicenter dataset.

Main Methods:

Retrospective case series of 240 adult patients with postprocedure acute endophthalmitis (2012-2022).
Organisms classified as surface commensals (e.g., coagulase-negative Staphylococcus) or nonsurface commensals (e.g., Streptococcus, Enterococcus) as virulence proxies.
Visual acuity and complication rates compared between groups, adjusting for confounders.

Main Results:

Infections with nonsurface commensals led to significantly worse final visual acuity (logMAR 2.14 vs 0.77).
Higher rates of interventions (27.5% vs 10.1%), phthisis (15.4% vs 1.1%), and enucleation/evisceration (12.8% vs 0%) were observed with virulent pathogens.
Virulent organisms remained independently associated with poorer visual outcomes in postinjection endophthalmitis.

Conclusions:

Infections with virulent, nonsurface commensal organisms are linked to worse outcomes in postprocedure endophthalmitis.
Pathogen-informed management strategies are supported by these findings.
Timely identification of virulent organisms is essential for optimizing patient care.