Related Experiment Video

Updated: Jan 9, 2026

The In ovo CAM-assay as a Xenograft Model for Sarcoma
12:44

The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 17, 2013

26.2K

Cardiac Angiosarcoma

Chu Chen1,2,3, Songlin Zhang4, Jian Yang2,3,5

  • 1Central Laboratory, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People's Hospital.

International Heart Journal
|November 30, 2025
PubMed

Insights

Primary cardiac angiosarcoma, an aggressive cancer, presents unique challenges. This case highlights a patient with right atrial angiosarcoma, treated with multimodal therapy, surviving 11 months.

Area of Science:

  • Cardiovascular Pathology
  • Cardiac Oncology
  • Medical Oncology

Background:

  • Angiosarcoma is the most aggressive primary malignant cardiac tumor.
  • It typically involves the right atrium and presents with nonspecific symptoms.
  • High invasiveness and rapid progression characterize this rare malignancy.

Purpose of the Study:

  • To report a case of primary cardiac angiosarcoma.
  • To discuss the diagnostic and therapeutic challenges.
  • To emphasize the need for evidence-based treatment guidelines.

Main Methods:

  • Case presentation of a patient with recurrent hemorrhagic pericardial effusion and cardiac tamponade.
  • Diagnostic imaging revealed a right atrial mass.
  • Surgical resection followed by histopathological confirmation of angiosarcoma.

Main Results:

  • Intraoperative findings confirmed extensive invasion into the pericardium and adjacent structures.
  • The patient underwent partial palliative resection.
  • Post-operative treatment included chemotherapy, immunotherapy, and targeted therapy, achieving 11 months of overall survival.

Conclusions:

  • Primary cardiac angiosarcoma requires a multidisciplinary approach.
  • Current therapeutic strategies present significant challenges.
  • Further research is needed to develop effective treatment guidelines for improved patient outcomes.

Keywords:
Cardiac tamponadePericardial effusionPrimary cardiac tumor

More Related Videos

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate07:31

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

4.2K
A Chronic Cardiac Ischemia Model in Swine Using an Ameroid Constrictor08:22

A Chronic Cardiac Ischemia Model in Swine Using an Ameroid Constrictor

Published on: October 9, 2017

11.0K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
374
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
314
Angina I: Introduction01:30

Angina I: Introduction

Definition and Symptoms: Angina (angina pectoris) is chest pain or discomfort caused by myocardial ischemia, which occurs when the heart muscle receives insufficient oxygen-rich blood. It typically manifests as pressing, squeezing, or crushing sensations in the chest and may radiate to the shoulders, arms, neck, jaw, or back.Primary Cause: In a healthy state, the coronary arteries can dilate (widen) to increase blood flow and meet the increased oxygen demand during physical activity or...
444
Angina III: Clinical Manifestations and Assessment01:29

Angina III: Clinical Manifestations and Assessment

Angina manifests as chest pain, tightness, or squeezing discomfort typically located behind the breastbone. It can radiate to the neck, jaw, shoulders, and inner aspects of the upper arms, most commonly the left arm. Patients may experience shortness of breath, fatigue, profuse sweating, dizziness, indigestion, heartburn, palpitations, anxiety, and vomiting as accompanying symptoms. This pain often lasts a few minutes and is triggered by physical exertion, emotional stress, heavy meals, or cold...
188
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
736