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Related Concept Videos

Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
Mitral Regurgitation IV: Nursing Management01:28

Mitral Regurgitation IV: Nursing Management

Mitral regurgitation (MR) is a condition where the mitral valve does not close properly, leading to the backward flow of blood from the left ventricle into the left atrium during systole. This condition can arise from various causes, including rheumatic fever, infective endocarditis, or degenerative valve disease. Effective nursing management is crucial to optimizing patient outcomes and involves comprehensive assessment and targeted interventions.Comprehensive Patient AssessmentA detailed...
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular tachycardia.
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...

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Updated: Jun 2, 2026

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
08:31

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Published on: October 16, 2021

Effective Transcatheter Mitral Valve Repair for Reverse Remodeling in Cancer Therapy-Related Cardiac Dysfunction.

Naoko Kawabata1,2, Naka Sakamoto1,2, Kenta Iyobe1

  • 1Division of Cardiology and Nephrology, Department of Internal Medicine, Asahikawa Medical University.

International Heart Journal
|May 31, 2026
PubMed
Summary
This summary is machine-generated.

Transcatheter edge-to-edge repair (TEER) effectively treated cancer therapy-related cardiac dysfunction (CTRCD) in a patient with severe heart failure and mitral regurgitation. This intervention led to significant reverse remodeling and improved cardiac function.

Keywords:
Cardiac magnetic resonance imagingEndomyocardial biopsyHeart failureTranscatheter edge-to-edge repair

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Area of Science:

  • Cardiology
  • Oncology
  • Cardiovascular Imaging

Background:

  • Cancer therapy-related cardiac dysfunction (CTRCD) is an emerging clinical challenge.
  • Standard heart failure treatments are often used for CTRCD, but specific therapies are lacking.
  • Transcatheter edge-to-edge repair (TEER) is effective for heart failure with secondary mitral regurgitation, but its role in CTRCD is uncertain.

Purpose of the Study:

  • To evaluate the effectiveness of TEER in a patient with CTRCD and severe heart failure.
  • To assess the impact of TEER on cardiac function and reverse remodeling in CTRCD.
  • To correlate imaging and pathological findings with clinical outcomes after TEER for CTRCD.

Main Methods:

  • Case report of a 47-year-old woman with CTRCD post-anthracycline and anti-HER2 therapy.
  • Comprehensive cardiac assessment including echocardiography, cardiac MRI, and endomyocardial biopsy.
  • Intervention with TEER for severe mitral regurgitation and persistent heart failure.
  • Follow-up assessment of cardiac function and reverse remodeling.

Main Results:

  • The patient presented with severe heart failure (LVEF 20%) and severe mitral regurgitation.
  • Cardiac MRI showed diffuse myocardial changes, and biopsy revealed fibrosis and cardiomyocyte damage.
  • TEER resulted in immediate hemodynamic improvement and significant recovery of LVEF to 61% at 12 months.
  • Pathological and imaging evaluations supported the observed reverse remodeling post-TEER.

Conclusions:

  • TEER can be a valuable therapeutic option for CTRCD with severe mitral regurgitation.
  • TEER may facilitate reverse remodeling and improve cardiac function in CTRCD patients.
  • This case highlights the potential of TEER in managing complex cardiovascular complications of cancer therapy.