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Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
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Pulmonary Tuberculosis I01:29

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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An In vitro Co-infection Model to Study Plasmodium falciparum-HIV-1 Interactions in Human Primary Monocyte-derived Immune Cells
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Fatal Mpox Coinfection in Advanced AIDS: A Case Report.

Yansi Lu1,2, Xiaoshu Yu1, Changjing Zhou1

  • 1Department of Infectious Diseases, Baise People's Hospital, Baise, Guangxi, People's Republic of China.

Infection and Drug Resistance
|December 1, 2025
PubMed
Summary
This summary is machine-generated.

Mpox (MPXV) disproportionately affects immunocompromised individuals, such as those with HIV. This case highlights severe mpox complications and rapid progression in an advanced AIDS patient, emphasizing the need for early recognition and treatment.

Area of Science:

  • Virology
  • Infectious Diseases
  • Public Health

Background:

  • Mpox virus (MPXV) is a zoonotic pathogen causing a global outbreak since 2022.
Keywords:
AIDSclinical manifestationsdifferential diagnosismpox virus

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  • Immunocompromised individuals, especially those with Human Immunodeficiency Virus (HIV), are disproportionately affected by mpox.
  • Advanced Acquired Immunodeficiency Syndrome (AIDS) represents a critical state of immune deficiency.