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Updated: Jan 9, 2026
Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
Published on: May 31, 2017
Engineering neural recovery: Micro/nano-structured materials for nerve regeneration.
Hui Zhang1, Junhui Sha1, Sixing Cao1
1State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province, High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, 210096, China.
Micro- and nano-structured materials are key for nerve tissue regeneration, guiding cell behavior and therapeutic delivery. This review covers their development, manufacturing, and applications in repairing peripheral nerves and spinal cord injuries.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Neuroscience
Background:
- Micro- and nano-structures significantly influence nerve cell behavior.
- These structures impact the distribution of therapeutic agents for nerve regeneration.
- Understanding these interactions is vital for successful neural tissue repair.
Purpose of the Study:
- To review the development of micro/nano-structured materials for neural tissue regeneration.
- To introduce key manufacturing strategies for these structures.
- To highlight applications and future prospects in nerve repair.
Main Methods:
- Electrospinning
- 3D printing
- Microfluidics
- Freezing casting
Main Results:
- Detailed review of various micro/nano-structured materials.
- Highlighting applications in peripheral nerve regeneration.
- Highlighting applications in spinal cord injury repair.
Conclusions:
- Micro/nano-structured materials offer significant potential for nerve regeneration.
- Challenges and future directions for next-generation materials are discussed.
- This review provides valuable insights for researchers in the field.
