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Skin and Soft Tissue Mucormycosis in Patients Receiving Bruton Tyrosine Kinase Inhibitors: Case Report and Literature

Eduardo Aparicio-Minguijón1, Nieves López-Muñoz2, Jorge Boán1

  • 1Unit of Infectious Diseases, Hospital Universitario "12 de Octubre," Instituto de Investigación Sanitaria Hospital "12 de Octubre,"  Madrid, Spain.

Open Forum Infectious Diseases
|December 1, 2025
PubMed

Insights

Bruton tyrosine kinase inhibitors (BTKis) increase invasive fungal disease risk. A fatal case of Lichtheimia-associated necrotizing fasciitis highlights this rare but severe complication, with a 37.5% mortality rate in BTKi users.

Area of Science:

  • Oncology
  • Infectious Diseases
  • Dermatology

Background:

  • Bruton tyrosine kinase inhibitors (BTKis) are increasingly used for B-cell malignancies.
  • BTKis are associated with an increased risk of invasive fungal infections.
  • Skin and soft tissue mucormycosis is a rare but severe manifestation of BTKi-associated fungal disease.
Keywords:
Bruton tyrosine kinase inhibitorchronic lymphocytic leukemiainfectionskin and soft tissue mucormycosiszanubrutinib

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