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Immunofluorescence Imaging of DNA Damage and Repair Foci in Human Colon Cancer Cells
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IGF1R promotes radiation-induced HSCs activation by regulating DNA-PKcs-mediated DNA damage repair

Jiguo Lin1, Gang Zhao1, Jie Feng1

  • 1NHC Key Laboratory of Radiobiology, College of Public Health, Jilin University, Changchun, China.

Frontiers in Cell and Developmental Biology
|December 1, 2025
PubMed
Summary

Ionizing radiation activates liver cells by promoting DNA repair through insulin-like growth factor 1 receptor (IGF1R) and DNA-PKcs interactions. Inhibiting this pathway may prevent radiation-induced liver fibrosis.

Keywords:
DNA damage repairDNA-dependent protein kinase catalytic subunithepatic stellate cellsinsulin-like growth factor 1 receptorionizing radiation

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