Decoding the gut microbiota-mitochondrial-inflammasome axis in cardiovascular disease

Area of Science:

• Cardiovascular Research
• Microbiome Science
• Mitochondrial Biology
• Inflammation Studies

Background:

• The gut microbiota influences host physiology through bioactive metabolites.
• Mitochondrial dysfunction and inflammation are implicated in cardiovascular disease (CVD).
• Interactions between gut microbiota, mitochondria, and inflammation are crucial for CVD pathogenesis.

Purpose of the Study:

• To review the signaling networks linking gut microbiota, mitochondrial function, and inflammation in CVD.
• To explore the role of microbial dysbiosis in inflammasome and mitochondrial-driven CVD.
• To identify potential therapeutic interventions targeting the gut microbiota-mitochondria-inflammasome axis.

Main Methods:

• Systematic review of current evidence from major scientific databases (PubMed, Google Scholar, Web of Science, ResearchGate).
• Analysis of molecular pathways involved in the gut microbiota-mitochondria-inflammasome axis.
• Examination of therapeutic strategies including microbiota modulation, mitochondrial antioxidants, and inflammasome inhibitors.

Main Results:

• Gut microbial dysbiosis contributes to cardiovascular pathophysiology via inflammasome and mitochondrial pathways.
• Key molecular pathways (e.g., TLR, PI3K/AKT, NLRP3) mediate the gut microbiota-mitochondria-inflammation triad's impact on CVD.
• Therapeutic interventions targeting this axis demonstrate potential cardioprotective effects.

Conclusions:

• The gut microbiota-mitochondria-inflammasome axis is a critical determinant of cardiovascular health.
• Understanding this triad provides mechanistic insights into CVD development.
• This axis represents a promising target for novel diagnostic and therapeutic strategies in cardiovascular medicine.