Periprosthetic Joint Infection in Patients with Benign Prostatic Hyperplasia: A Systematic Review and Meta-analysis

Area of Science:

• Orthopedic Surgery
• Urology
• Infectious Diseases

Background:

• Periprosthetic joint infection (PJI) is a major complication in orthopedic surgery.
• Benign prostatic hyperplasia (BPH) is a common condition affecting the lower urinary system.
• A potential association between BPH and PJI has been suggested but lacks conclusive evidence.

Purpose of the Study:

• To investigate the relationship between benign prostatic hyperplasia (BPH) and the risk of periprosthetic joint infection (PJI).
• To synthesize existing evidence through a meta-analysis to clarify the association between BPH and PJI incidence.

Main Methods:

• A systematic review and meta-analysis were conducted following PRISMA 2020 guidelines.
• Literature searches were performed on PubMed, EBSCO, and ProQuest databases.
• Data from five studies were analyzed using a random-effects model with Comprehensive Meta-Analysis software.

Main Results:

• The meta-analysis revealed no statistically significant correlation between BPH and an increased likelihood of PJI (OR 1.228, P=0.172).
• Subgroup analyses for total hip arthroplasty and total knee arthroplasty also showed no significant associations.
• No direct link was substantiated between BPH and PJI incidence.

Conclusions:

• Benign prostatic hyperplasia (BPH) is not directly associated with an elevated risk of periprosthetic joint infection (PJI).
• Other factors, potentially related to infections common in BPH patients, might influence PJI rates.
• Further research is warranted to explore indirect relationships and confounding variables.