Target-Responsive Lanthanide Coordination Nanoparticles for Time-Resolved Photoluminescence and SERS Dual-Mode...

Area of Science:

• Nanomaterials Science
• Analytical Chemistry
• Biomedical Engineering

Background:

• Lanthanide coordination nanoparticles (Ln-CNPs) show promise for optical biosensing.
• Conventional synthesis methods yield poorly dispersed nanoparticles with uncontrolled structures.
• There is a need for Ln-CNPs with tunable properties and improved dispersibility for sensitive detection.

Purpose of the Study:

• To develop a facile coordination-driven self-assembly strategy for preparing Ln-CNPs with tunable properties.
• To demonstrate the utility of these Ln-CNPs in a dual-mode TRPL/SERS biosensing platform.
• To achieve accurate detection of analytes in complex biological matrices.

Main Methods:

• Coordination-driven self-assembly of adenosine diphosphate (ADP) with lanthanide ions (Ln3+) to form Ln-CNPs.
• Characterization of Ln-CNP morphology, monodispersity, and luminescence properties.
• Development of a dual-mode TRPL/SERS platform using ADP-Europium (Eu) CNPs for tetracycline (TC) detection.

Main Results:

• Synthesized Ln-CNPs with controllable morphology, excellent monodispersity, and long-lived luminescence.
• Demonstrated TRPL detection with ADP-Eu and ADP-Terbium (Tb) CNPs and potential MRI applications with ADP-Gadolinium (Gd) CNPs.
• Achieved sensitive dual-mode TRPL/SERS detection of TC down to 10^-9 M, with high accuracy and precision in serum samples.

Conclusions:

• The developed coordination-driven self-assembly strategy enables the engineering of multifunctional Ln-CNPs.
• The TRPL/SERS dual-mode platform offers enhanced accuracy for analyte detection in complex biological systems.
• This work provides a generalizable paradigm for developing advanced Ln-CNP-based biosensors.