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Updated: Jan 6, 2026
Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
Published on: October 28, 2022
Hemodynamics in infants with hypoxemic ischemic encephalopathy: pathophysiology and beyond
Aimann Surak1, Georg M Schmölzer2,3, Patrick J McNamara4
1Division of Neonatology, University of Alberta, Edmonton, AB, Canada. aimann@ualberta.ca.
Abstract:
Perinatal asphyxia is a critical event causing variable degrees of multiorgan dysfunction. Hypoxemic ischemic encephalopathy (HIE) features the brain exposure to asphyxia, and most of the underlying pathophysiology is a related to impaired blood flow and oxygen delivery to the brain. Cardiovascular compromise is common in this context and often necessitates initiation of inotropic support. In this article, we highlight the neonatal hemodynamics and its derangements, following asphyxia, and we highlight the pitfalls in the current hemodynamic approach.
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