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Related Concept Videos

Long-term Potentiation01:25

Long-term Potentiation

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
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Long-term Potentiation01:35

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Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
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Updated: Jan 9, 2026

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The Dynamic Interaction between Procedural Learning and Resting-State Functional Connectivity in Self-Limited Focal

Coralie Rouge1,2,3, Elodie Juvené4, Dorine Van Dyck4,5

  • 1Neuropsychology and Functional Neuroimaging Research Unit, Center for Research in Cognition & Neurosciences (CRCN), Université libre de Bruxelles (ULB), ULB Neurosciences Institute (UNI), 50 Avenue F.D. Roosevelt CP191, Brussels, 1050, Belgium. coralie.rouge@ulb.be.

Brain Topography
|December 1, 2025
PubMed
Summary
This summary is machine-generated.

Children with self-limited focal epilepsies of childhood (SeLFE) show impaired procedural learning (PL) and atypical brain network reorganization. Interictal epileptic discharges negatively impact PL acquisition in these patients.

Keywords:
Functional connectivityInterictal epileptic dischargesMagnetoencephalographyProcedural learningResting-stateSelf-limited focal epilepsies of childhood

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Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Epilepsy Research

Background:

  • Procedural learning (PL) network functions are unexplored in children with self-limited focal epilepsies of childhood (SeLFE).
  • SeLFE impacts sensorimotor, language, and cognitive abilities, suggesting potential PL deficits.
  • Resting-state functional connectivity (rsFC) dynamics during learning are unknown in pediatric epilepsy.

Purpose of the Study:

  • Investigate PL abilities in children with SeLFE.
  • Examine the interaction between PL and rsFC reorganization in SeLFE.
  • Determine the impact of interictal epileptic discharges (IEDs) on PL and rsFC.

Main Methods:

  • Used a serial reaction time task and resting-state magnetoencephalography (MEG) in 10 children with SeLFE and 28 typically developing (TD) controls.
  • Assessed pre- to post-learning rsFC changes using band-limited power envelope correlation.
  • Regressed interictal epileptic discharges (IEDs) from rsFC data in the SeLFE group.

Main Results:

  • Children with SeLFE exhibited atypical pre- to post-learning rsFC changes in widespread brain networks (theta, alpha, low beta bands).
  • Reduced PL performance was observed in children with SeLFE compared to TD peers.
  • Lower PL performance correlated negatively with sleep IED frequency in SeLFE patients.

Conclusions:

  • This is the first MEG study demonstrating reduced PL and atypical rsFC reorganization post-learning in children with SeLFE.
  • The pathophysiology of SeLFE, including chronic IEDs, detrimentally affects PL acquisition and brain-behavior processes.
  • Findings highlight the need to consider PL network development in managing pediatric epilepsy.