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Updated: Jan 9, 2026

Trace Fear Conditioning in Mice

Trace Fear Conditioning in Mice

Published on: March 20, 2014

Aging-independent decrease of complex multi-spine boutons in hippocampal area CA1 after contextual fear conditioning.

Raquel Martinez-Serra¹, Suji Lee¹, Igor Kraev²

¹Department of Basic and Clinical Neuroscience, King's College London, London, UK.

Molecular Brain

|December 2, 2025

Summary

This summary is machine-generated.

Multi-innervated dendritic spines (MISs) aid memory in aged mice. Unexpectedly, multi-spine bouton (MSB) complexity decreases after fear conditioning in both young and aged mice, suggesting a role in memory recall.

Keywords:

Aging Hippocampus Memory Multi-synapse bouton

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Last Updated: Jan 9, 2026

Trace Fear Conditioning in Mice

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Published on: March 20, 2014

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Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

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Published on: August 11, 2019

Area of Science:

Neuroscience
Synaptic Plasticity
Memory Research

Background:

Long-lasting synaptic changes are crucial for memory storage and recall.
Previous research identified multi-innervated dendritic spines (MISs) in aged mice post-memory formation.
The role of multi-spine boutons (MSBs) in memory recall remained unclear.

Purpose of the Study:

To investigate the changes in multi-spine bouton (MSB) complexity after contextual fear conditioning (CFC).
To determine if aging impacts MSB complexity changes following CFC.
To explore the potential role of MSB complexity in memory recall.

Main Methods:

Re-analysis of existing three-dimensional electron microscopy images.
Ultrastructural analysis of hippocampal CA1 stratum radiatum 24 hours after CFC.
Comparison of MSB complexity in young and aged mice.

Main Results:

MSB complexity unexpectedly decreased in the CA1 stratum radiatum 24 hours after CFC.
This decrease in MSB complexity was observed in both young and aged mice.
Aging did not influence the observed change in MSB complexity.

Conclusions:

A decrease in MSB complexity, not an increase, occurs after CFC.
This synaptic change is independent of age.
Reduced MSB complexity may be essential for specific memory recall after fear conditioning.