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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Triplet nitrene-mediated photocatalytic azidation of tertiary C(sp3)-H bonds
Noriaki Shimamoto1, Norihito Arichi1, Hiroaki Ohno1
1Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
Abstract:
A photocatalytic C(sp3)-H azidation involving a triplet nitrene as a hydrogen atom abstractor is described. The key nitrene intermediate is generated through energy transfer to a sulfonyl azide, which also functions as an azide source. This method exhibits excellent selectivity for tertiary C-H bonds and is applicable to leucine-containing dipeptides.
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