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Chronic Inflammation in Patients with Chronic Coronary Syndrome Who Have Been Taking Lipid-Lowering Drugs as a

Runze Zhu1,2,3, Wenxian Wang1,2,3, Yan Gao2,3

  • 1School of Radiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, People's Republic of China.

Journal of Inflammation Research
|December 2, 2025
PubMed

Insights

In patients with chronic coronary syndrome on statins, high systemic inflammation (SIRI) and epicardial adipose tissue (EAT) volume are key risk factors for adverse events. These factors interact, worsening prognosis beyond lipid levels.

Area of Science:

  • Cardiology
  • Biomedical research
  • Inflammation research

Background:

  • Patients with coronary heart disease on long-term lipid-lowering agents often have low lipid levels but remain at risk due to systemic inflammation.
  • Elevated systemic inflammation is a significant risk factor for poor prognosis in individuals with chronic coronary syndrome (CCS).

Purpose of the Study:

  • To investigate the relationship between systemic inflammation and adverse outcomes in CCS patients.
  • To explore the synergistic interaction between systemic inflammation and epicardial adipose tissue (EAT) in CCS patients.

Main Methods:

  • A retrospective cohort study of 278 CCS patients on long-term statin therapy.
  • Cardiovascular magnetic resonance (CMR) imaging and blood tests were used to measure EAT volume and systemic inflammatory response index (SIRI).
  • Cox regression and mediation analyses were employed to assess associations and interrelationships.

Main Results:

  • Both SIRI and indexed EAT volume were independently associated with major adverse cardiovascular events (MACEs).
  • Combining SIRI and EAT volume improved MACE prediction.
  • EAT volume and SIRI showed a bidirectional partial mediation effect on MACEs and extracellular volume (ECV).

Conclusions:

  • Elevated SIRI and increased EAT volume are critical risk factors in CCS patients on statins, surpassing lipid levels.
  • SIRI and EAT volume interact, collectively contributing to a poor prognosis in this patient group.
Abstract

Keywords:
cardiovascular magnetic resonancechronic coronary syndromechronic inflammationepicardial adipose tissuesystemic inflammatory response index

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