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Extracutaneous Sporotrichosis With Dissemination to the Brain in a Patient Taking Biologic Medications: A Case Report

Kailey N Nguyen1, Donna Defreitas2, Bryan Youree2

  • 1Internal Medicine, Baylor Scott & White All Saints Medical Center, Fort Worth, USA.

Cureus
|December 2, 2025
PubMed

Insights

Biologic medications for psoriatic arthritis can increase the risk of severe fungal infections like sporotrichosis. This case highlights central nervous system dissemination and effective treatment with amphotericin B.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Immunology

Background:

  • Sporotrichosis is a fungal infection caused by *Sporothrix* species.
  • It can manifest in localized cutaneous or disseminated forms.
  • Immunosuppression is a risk factor for severe disease.
Keywords:
chronic use of biologicsdisseminated extracutaneous sporotrichosisdisseminated sporotrichosisimmunosuppressed patientinterleukin-23 inhibitorrheumatoid arthritissporothrix schenckii fungus

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