Intramolecular Photocyclization of Enamide Linked 1,5-Dienes Enables Divergent Synthesis of Pyridin-2-one Derivatives
Xiaoyue Ren1, Tian-Yu Sun2, Xiao-Feng Xia1
1Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi, Jiangsu 214122, China.
Abstract:
An energy transfer (EnT) catalyzed photocyclization process for the divergent synthesis of substituted 3,4-dihydropyridin-2(1H)-ones and pyridine-2-ones in sustainable solvents is realized by tuning the reaction conditions. The present metal-free system exhibits a high reaction efficiency and good functional group tolerance. Notably, the TEMPO-trap experiment, control experiments, and DFT calculations have offered evidence supporting the proposed catalytic cycle.
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