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Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
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Un-LOX-ing tumor immune barriers
Tuyen T Dang1, Srinivas Malladi2
1Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Developmental Cell
|December 2, 2025
Abstract:
In this issue of Developmental Cell, Zhang et al. report the identification of two transcriptionally distinct renal cell carcinoma tumor thrombus subtypes. The aggressive TT1 subtype is characterized by LOX-expressing cancer cells within an immunosuppressive microenvironment dominated by THBS2+ fibroblasts and GPNMB+ macrophages that exclude CD8+ T cells.
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