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First In Vivo 23Na Human Imaging at 10.5 T Using a Combined Sodium-Proton Transceiver Body Array.

Simon Schmidt1,2, Arcan M Ertürk1, Gregory J Metzger1

  • 1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, USA.

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Summary
This summary is machine-generated.

This study presents the first in vivo human 23Na MRI at 10.5 Tesla, utilizing a novel dual-tuned transceiver array and a self-gating technique for motion compensation. This advancement enables clearer renal imaging and quantitative sodium studies.

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10.5 Tbody MRIself‐gatingsodium MRIultra‐high field MRI

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Area of Science:

  • Medical Imaging
  • Magnetic Resonance Imaging (MRI)
  • Biophysics

Background:

  • High-field MRI (≥10.5T) offers potential for enhanced signal-to-noise ratio and spectral resolution.
  • 23Na MRI provides unique insights into tissue sodium concentration and homeostasis.
  • Respiratory motion significantly degrades image quality in human MRI, necessitating effective compensation strategies.

Purpose of the Study:

  • To demonstrate the feasibility of the first in vivo human 23Na MRI at 10.5 Tesla.
  • To evaluate a novel dual-tuned transceiver body array for simultaneous 23Na and 1H imaging.
  • To assess a self-gating approach for respiratory motion compensation in 10.5T human MRI, with a focus on renal imaging.

Main Methods:

  • A custom eight-channel dual-tuned 23Na-loop / 1H-dipole transceiver array was designed and constructed.
  • Electromagnetic simulations were validated against phantom measurements for B1+ and SAR.
  • A motion phantom and in vivo studies in three healthy volunteers were used to evaluate the self-gating technique for respiratory motion compensation.

Main Results:

  • The dual-tuned array demonstrated good agreement between simulated and measured electromagnetic parameters.
  • Self-gating accurately tracked respiratory motion in both 23Na and 1H acquisitions (correlation coefficients > 0.979).
  • Motion binning significantly improved image sharpness and anatomical detail in both phantom and in vivo datasets.

Conclusions:

  • The first in vivo human 23Na MRI at 10.5 Tesla was successfully achieved.
  • The developed dual-tuned array and validated self-gating technique are suitable for 10.5T human imaging.
  • This work paves the way for advanced quantitative sodium imaging and improved diagnostic capabilities.