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Psychoneuroimmunology: Diabetes and Cancer01:19

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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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Consensus Co-Expression Analysis Identifies A Common Set Of Co-Expressed Genes Associated With Diabetic Peripheral

Kord M Kober, Esther Chavez-Iglesias, Nam Woo Cho

    Biorxiv : the Preprint Server for Biology
    |December 3, 2025
    PubMed
    Summary

    Diabetic peripheral neuropathy (DPN) and chemotherapy-induced peripheral neuropathy (CIPN) share common molecular pathways. Targeting metabolic reprogramming, stress, and cell death may offer new therapeutic strategies for both conditions.

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    Area of Science:

    • Neuroscience
    • Genomics
    • Systems Biology

    Background:

    • Diabetic peripheral neuropathy (DPN) and chemotherapy-induced peripheral neuropathy (CIPN) present significant clinical challenges with few treatment options.
    • Despite different etiologies, DPN and CIPN may share underlying molecular mechanisms amenable to therapeutic intervention.

    Purpose of the Study:

    • To identify conserved molecular mechanisms between DPN and CIPN using a systems biology approach.
    • To uncover potential therapeutic targets by analyzing shared gene expression patterns.

    Main Methods:

    • Consensus Weighted Gene Co-expression Network Analysis (WGCNA) was applied to two independent datasets (GSE185011 and GSE173610).
    • Analysis focused on identifying gene co-expression modules conserved across DPN and CIPN models (peripheral blood mononuclear cells and sensory neurons).

    Main Results:

    • A significant 193-gene module (ME3/brown) was conserved and strongly associated with both DPN and CIPN.
    • Functional enrichment analysis highlighted pathways including Glycolysis, FoxO signaling, Apoptosis, and Autophagy within this module.

    Conclusions:

    • A convergent molecular signature involving metabolic reprogramming, transcriptional stress, and programmed cell death underlies both DPN and CIPN.
    • These findings offer a systems-level perspective for developing novel therapies targeting shared pathological pathways in peripheral neuropathies.